The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation
Mina S. Khella, Philipp Schnee, Sara Weirich, Tan Bui, Alexander Bröhm, Pavel Bashtrykov, Jürgen Pleiss, Albert Jeltsch
The paper shows that the T1150A mutation in NSD2 leads to hyperactivity and H3K36 trimethylation, suggesting a role in leukemia.
Journal of Biological Chemistry · May 5, 2023Peer-reviewedMolecular Biology