Pavel Bashtrykov

The paper develops a BiAD sensor to detect locus-specific histone acetylation dynamics in living cells using fluorescence microscopy and validates its function at the TTC34 locus.

This study shows that H3K14 acetylation directs SETDB1 activity via its Triple Tudor Domain, enabling H3K9 methylation and heterochromatin formation.

This study shows UHRF1 has non-canonical roles beyond DNMT1 activation in maintaining DNA methylation homeostasis in cancer cells.

This study identifies a novel read-out mechanism of UHRF1-TTD binding to H3K4me1-K9me2/3 double marks, showing its role in gene down-regulation and chromatin binding.

The paper shows that the T1150A mutation in NSD2 leads to hyperactivity and H3K36 trimethylation, suggesting a role in leukemia.

This study characterizes the structure-function differences between DNMT3A and DNMT3B, revealing distinct mechanisms of de novo DNA methylation and their implications in epigenomic alterations.