Albert Jeltsch

The paper identifies DNA methylation changes during IDH-mutant glioma progression, links them to TET enzyme activity, and develops a methylation-based grading system that outperforms WHO grading.

The paper uses a hybrid model to show that faster cell division increases epigenetic memory stability in bacteria, challenging the expectation that slower division would enhance memory.

The paper develops a BiAD sensor to detect locus-specific histone acetylation dynamics in living cells using fluorescence microscopy and validates its function at the TTC34 locus.

This study shows that H3K14 acetylation directs SETDB1 activity via its Triple Tudor Domain, enabling H3K9 methylation and heterochromatin formation.

This study shows UHRF1 has non-canonical roles beyond DNMT1 activation in maintaining DNA methylation homeostasis in cancer cells.

This study identifies a novel read-out mechanism of UHRF1-TTD binding to H3K4me1-K9me2/3 double marks, showing its role in gene down-regulation and chromatin binding.

The paper identifies a positive feedback loop where SETD6 methylates E2F1 at K117, enhancing SETD6 expression, and shows that this methylation is critical for maintaining SETD6 levels.

The paper shows that the T1150A mutation in NSD2 leads to hyperactivity and H3K36 trimethylation, suggesting a role in leukemia.

This study characterizes the structure-function differences between DNMT3A and DNMT3B, revealing distinct mechanisms of de novo DNA methylation and their implications in epigenomic alterations.