ProteinSage: From implicit learning to explicit structural constraints for efficient protein language modeling
Lingdong Shen, Linlin Chao, Tang Liu, Qi Liu, Guowei Zhou, Hao Wang, Xinyue Dong, Tianhong Li, Xiaoming Zhang, jinren Ni
ProteinSage uses structural constraints during pretraining to improve protein language modeling with less data, achieving competitive performance on structure-aware tasks.
bioRxiv · Sep 9, 2026 · PreprintBioinformatics