Guowei Zhou

ProteinSage uses structural constraints during pretraining to improve protein language modeling with less data, achieving competitive performance on structure-aware tasks.

This paper introduces modality-chain reasoning for multimodal protein modeling and design, showing improved performance in structure prediction, inverse folding, and fitness prediction compared to existing models.

RNAGenesis is a foundation model for RNA therapeutics that integrates sequence, structure, and function prediction, achieving state-of-the-art performance on multiple tasks and enabling functional RNA design.