Trymethylamine-N-oxide, a gut-derived metabolite, induces myofibroblastic activation of valvular interstitial cells through endoplasmic reticulum stress
Samanvitha Deepthi Sudi, Sai Drishya Suresh, Tanmayee Kolli, Ana Maria Porras
This study shows TMAO induces myofibroblastic activation of valvular interstitial cells via endoplasmic reticulum stress, contributing to aortic valve disease.
bioRxiv · Feb 6, 2025 · PreprintCell Biology