DNA Adenine Methylation Clock in Brain Aging and Alzheimer's Disease Progression
Abdur Rahim, Xiaomei Zhan, Qiyuan Han, Allysha O’Donnell, Angela Jeong, Guru S. Madugundu, Suresh S. Pujari, Monica Kruk, Xinlong Luo, Ling Li, Tao P. Wu, Natalia Y. Tretyakova
This study quantifies N6-methyldeoxyadenosine (N6medA) in human brain tissue and links its age-related accumulation to Alzheimer's disease and cognitive impairment.
bioRxiv · Mar 6, 2026 · PreprintBiochemistry