Author

Natalia Y. Tretyakova

University of MinnesotaORCID 0000-0002-0621-6860Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Monica KrukiD· 3 shared Abdur RahimiD· 2 shared Allysha O’Donnell· 1 shared Andrew T. RajczewskiiD· 1 shared Angela JeongiD· 1 shared Brian L. RuisiD· 1 shared C. E. Campbell· 1 shared Cesar I. CyuzuzoiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiochemistry

Monica KrukORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bivalent Inhibitor Development for a Dynamic Epigenetic Tandem Reader Protein Using a Combinatorial Histone Code

Joseph E. McPherson, Molly Sneddon, Richard Kofi Begyinah, Kesavan Babu, Kerstin E. Peterson, Ryan F. Friess, Thomas G. Smith, Natalia Y. Tretyakova, Marcus M. Fischer, William C. K. Pomerantz

This study identifies H3K4me3K14ac as the specific histone modification recognized by BPTF's PHD BRD cassette, designs a bivalent inhibitor MJ-1, and provides structural insights for therapeutic development.

bioRxiv · Oct 16, 2026 · PreprintBiochemistry

Living Cells Employ Ubiquitin-Proteasomal System and Nucleotide Excision Repair Pathways to Remove Reactive Oxygen Species-Induced DNA-Protein Crosslinks (ROS-DPCs).

Cesar I. Cyuzuzo, Monica Kruk, Qi Zhang, Duha Alshareef, James Harmon, Yuichi Machida, Harrison W. VanKoten, Swati S. More, C. E. Campbell, Natalia Y. Tretyakova

This study identifies ROS-DPCs in human cells and shows that the ubiquitin-proteasomal system, SPRTN, and NER remove them, with a GSH analog preventing their formation.

bioRxiv · Mar 13, 2026 · PreprintBiochemistry

DNA Adenine Methylation Clock in Brain Aging and Alzheimer's Disease Progression

Abdur Rahim, Xiaomei Zhan, Qiyuan Han, Allysha O’Donnell, Angela Jeong, Guru S. Madugundu, Suresh S. Pujari, Monica Kruk, Xinlong Luo, Ling Li, Tao P. Wu, Natalia Y. Tretyakova

This study quantifies N6-methyldeoxyadenosine (N6medA) in human brain tissue and links its age-related accumulation to Alzheimer's disease and cognitive impairment.

bioRxiv · Mar 6, 2026 · PreprintBiochemistry

TET1 Functions as a Tumor Suppressor in Lung Adenocarcinoma Through Epigenetic Remodeling and Immune Modulation

Abdur Rahim, Brian L. Ruis, Andrew T. Rajczewski, Monica Kruk, Natalia Y. Tretyakova

This study shows TET1 acts as a tumor suppressor in lung adenocarcinoma by promoting antitumor immunity and inhibiting cell proliferation and migration.

Epigenetics & Chromatin · Aug 11, 2025Peer-reviewedCancer Biology