Alteration of long and short-term hematopoietic stem cell ratio causes myeloid-biased hematopoiesis
Katsuyuki Nishi, Taro Sakamaki, Akiomi Nagasaka, Kevin Shuolong Kao, Kay Sadaoka, Masahide Asano, Nobuyuki Yamamoto, Akifumi Takaori‐Kondo, Masanori Miyanishi
The paper shows that myeloid-biased hematopoiesis in aging is due to altered LT-HSC/ST-HSC ratios, not HSC clone heterogeneity.
eLife · Aug 27, 2025Peer-reviewedDevelopmental Biology