Pharmacology & ToxicologybioRxivPreprint
Sex-specific amplification of IKr-blocker-induced action potential prolongation by reduced female IKs repolarization reserve: a computational study using the O'Hara-Rudy human ventricular model
Tarun Aadithya Magesh Raghavan
This paper uses a computational model to show that reduced IKs conductance in female cardiomyocytes amplifies the effect of IKr blockers, leading to greater action potential prolongation and increased risk of arrhythmia.
DOI 10.64898/2026.05.07.723338