The circadian clock regulates KCNH2 (hERG) promoter activity through daily temperature rhythms.
Ezekiel R. Rozmus, Isabel G. Stumpf, David J. Schneider, Alexander P. Alimov, Taylor H Pierce, Tooraj Mirshahi, Brian P. Delisle, Elizabeth A. Schroder
This study shows that temperature cycles drive circadian regulation of the KCNH2 promoter through BMAL1:CLOCK binding at a conserved E-box.
bioRxiv · Sep 29, 2026 · PreprintCell Biology