Circadian Rhythms of Whole-Body Metabolite Abundance in Drosophila are Largely Driven by Time of Feeding
Sumit Saurabh, Charlene Y. P. Guerrero, Madelyn R. Cusick, Amanda J. Samaras, Taylor M. Stephenson, Sebastian L. Kirkpatrick, Gregory J. Matthews, Daniel J. Cavanaugh
This study shows that feeding cycles, not direct circadian clock control, drive most metabolic rhythms in Drosophila, even though metabolic gene expression is locally clock-regulated.
bioRxiv · Dec 16, 2025 · PreprintMolecular Biology