Tumor suppressor collateral damage screens reveal mRNA homeostasis protein HBS1L as a novel vulnerability in ch9p21 driven FOCAD deleted cancer
Hongxiang Zhang, Matthew R. Tonini, Lauren Catherine M. Martires, Helena N. Jenkins, Charlotte B. Pratt, Eden N. Gordon, Shan-Chuan Zhao, Ashley H. Choi, Samuel R. Meier, Tenzing Khendu, Shangtao Liu, Binzhang Shen, Hannah Stowe, Katerina Pashiardis, Xuewen Pan, , Teng Teng
The paper identifies HBS1L as a synthetic lethal target in FOCAD-deleted cancer through combinatorial CRISPR screens and validates its dependency via genetic manipulation and in vivo experiments.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · Oct 15, 2025Peer-reviewedCancer Biology