CHOP promotes the transition to chronic integrated stress response signaling with suppression of hepatocyte identity
Theo F Velarde, Kaihua Liu, Zewei Zhang, Reed C. Adajar, Chaoxian Zhao, Huojun Cao, D. Thomas Rutkowski
This study shows CHOP promotes chronic integrated stress response signaling and suppresses hepatocyte identity in vivo by exacerbating ER stress and altering gene regulation.
bioRxiv · May 15, 2026 · PreprintCell Biology