M. tuberculosis meets European Lead Factory - identification and structural characterization of novel Rv0183 inhibitors using X-ray crystallography
Lina Riegler-Berket, Laura Gödl, Nakia Polidori, Philipp Aschauer, Christoph Grininger, Gareth Prosser, Jörg Lichtenegger, Theo Sagmeister, Lena Parigger, Christian C. Gruber, Norbert Reiling, Monika Oberer
This study identifies and characterizes novel Rv0183 inhibitors using high-throughput screening and X-ray crystallography, demonstrating species-selective inhibition against Mycobacterium tuberculosis.
bioRxiv · Jun 12, 2025Biochemistry