Axonal transcriptome reveals upregulation of PLK1 as a protective mechanism in response to increased DNA damage in FUSP525L spinal motor neurons
Vitaly L. Zimyanin, Banaja P. Dash, Dajana Großmann, Theresa Simolka, Hannes Glaß, Riya Verma, Vivek Khatri, Christopher D. Deppmann, Eli R. Zunder, Stefanie Redemann, Andreas Hermann
The paper uses compartment-specific RNA-sequencing to analyze axonal and somatodendritic transcriptomes of FUS-ALS motor neurons, identifying PLK1 upregulation as a protective response to DNA damage.
bioRxiv · Nov 20, 2024 · PreprintNeuroscience