Eli R. Zunder

A Single-Cell Signaling Atlas of Spinal Cord BDNF Responses Reveals Determinants Beyond Receptor Expression

The paper constructs a single-cell signaling atlas of BDNF responses in spinal cord cells, revealing that receptor stoichiometry and cell identity determine signaling outcomes.

IgA antibodies against oxidation-specific epitopes are generated by double negative B cells and are associated with impaired lung function in fibrotic interstitial lung diseases.

This study identifies elevated anti-oxidation-specific epitope (OSE) IgA antibodies in fibrotic interstitial lung diseases (fILD) and links them to impaired lung function and a specific B cell subset.

Extrinsic Apoptosis and Necroptosis in Telencephalic Development: A Single-Cell Mass Cytometry Study

This study uses single-cell mass cytometry to show that deleting RIPK3 and Caspase-8 increases cell count in the mouse telencephalon, indicating non-exclusive roles for extrinsic apoptosis and necroptosis in developmental cell elimination.

Characterizing microglial signaling dynamics during inflammation using single-cell mass cytometry

This study uses single-cell mass cytometry to analyze microglial signaling dynamics during inflammation, revealing distinct responses to LPS and Poly(I:C) and the modulating effect of astrocytes.

Axonal transcriptome reveals upregulation of PLK1 as a protective mechanism in response to increased DNA damage in FUSP525L spinal motor neurons

The paper uses compartment-specific RNA-sequencing to analyze axonal and somatodendritic transcriptomes of FUS-ALS motor neurons, identifying PLK1 upregulation as a protective response to DNA damage.

A hyperparameter-randomized ensemble approach for robust clustering across diverse datasets

This paper introduces an ensemble clustering method with hyperparameter randomization that improves clustering accuracy and interpretability across diverse datasets.

Live cell imaging of ATP levels reveals metabolic compartmentalization within motoneurons and early metabolic changes in FUS ALS motoneurons.

The paper uses live cell imaging to show reduced ATP levels in FUS-ALS motoneurons, linking metabolic changes to disease vulnerability.

A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry

This study uses single-cell mass cytometry to map somatosensory development in mouse dorsal root ganglia, identifying distinct cell states and highlighting differences between protein and mRNA expression.

A developmental atlas of the mouse brain by single-cell mass cytometry

The paper constructs a developmental atlas of the mouse brain using single-cell mass cytometry, identifying 85 molecularly distinct cell populations and revealing discrepancies between protein and mRNA abundances.