Christopher D. Deppmann

Palmitoylation of p75 neurotrophin receptor is required for retrograde regressive signaling

This study shows that palmitoylation of p75NTR at C281 is essential for retrograde signaling by enabling the formation of p75ICD-positive endosomes for axonal transport and apoptosis.

A Single-Cell Signaling Atlas of Spinal Cord BDNF Responses Reveals Determinants Beyond Receptor Expression

The paper constructs a single-cell signaling atlas of BDNF responses in spinal cord cells, revealing that receptor stoichiometry and cell identity determine signaling outcomes.

Extrinsic Apoptosis and Necroptosis in Telencephalic Development: A Single-Cell Mass Cytometry Study

This study uses single-cell mass cytometry to show that deleting RIPK3 and Caspase-8 increases cell count in the mouse telencephalon, indicating non-exclusive roles for extrinsic apoptosis and necroptosis in developmental cell elimination.

BDNF receptor balance gates AgRP-to-PVH fiber density and stimulation evoked feeding across caloric states

The paper shows that the balance of BDNF receptors TrkB and p75NTR in AgRP neurons controls PVH fiber density and stimulation-evoked feeding across different caloric states.

Axonal spheroids are regulated by Schwann cells after peripheral nerve injury

The paper identifies how Schwann cells regulate axonal spheroid fates after peripheral nerve injury in zebrafish, showing three outcomes: shrinking, breakdown, and uniform disappearance.

Characterizing microglial signaling dynamics during inflammation using single-cell mass cytometry

This study uses single-cell mass cytometry to analyze microglial signaling dynamics during inflammation, revealing distinct responses to LPS and Poly(I:C) and the modulating effect of astrocytes.

A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs

This paper shows small-molecule GLP1RAs modulate reward processing via a specific neural circuit in the central amygdala, affecting dopamine release and hedonic feeding.

Axonal transcriptome reveals upregulation of PLK1 as a protective mechanism in response to increased DNA damage in FUSP525L spinal motor neurons

The paper uses compartment-specific RNA-sequencing to analyze axonal and somatodendritic transcriptomes of FUS-ALS motor neurons, identifying PLK1 upregulation as a protective response to DNA damage.

Sarm1 Gates the Transition from Protective to Repair Schwann Cell States Following Nerve Injury

This study shows Sarm1 promotes the transition from protective to repair Schwann cell states after nerve injury, with implications for neuropathies and neurodegenerative diseases.

Live cell imaging of ATP levels reveals metabolic compartmentalization within motoneurons and early metabolic changes in FUS ALS motoneurons.

The paper uses live cell imaging to show reduced ATP levels in FUS-ALS motoneurons, linking metabolic changes to disease vulnerability.

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

The paper identifies TrkA as a cargo in sympathetic neuron-derived extracellular vesicles and shows it is retrogradely transported and secreted.

A leptin-responsive hypothalamic circuit inputs to the circadian feeding network

The paper identifies a leptin-responsive hypothalamic circuit that influences circadian feeding rhythms by modulating SCN activity and food entrainment.

A developmental atlas of somatosensory diversification and maturation in the dorsal root ganglia by single-cell mass cytometry

This study uses single-cell mass cytometry to map somatosensory development in mouse dorsal root ganglia, identifying distinct cell states and highlighting differences between protein and mRNA expression.

A developmental atlas of the mouse brain by single-cell mass cytometry

The paper constructs a developmental atlas of the mouse brain using single-cell mass cytometry, identifying 85 molecularly distinct cell populations and revealing discrepancies between protein and mRNA abundances.

p75NTR and DR6 regulate distinct phases of axon degeneration demarcated by spheroid rupture.

The paper identifies distinct phases of axon degeneration regulated by p75NTR and DR6, showing calcium flux and spheroid rupture as key events.