MTALTCO1: a 259 amino-acid long mtDNA-encoded alternative protein that challenges conventional understandings of mitochondrial genomics
Francis Robitaille, Amy Campbell, Aziz Ben Hadj, Sarah Cornet, Ludovic Nadeau-Lachance, Thierry Niaison, Thierry Choquette, Liam Nyffeler, Xavier Roucou, Annie Angers, Sophie Breton
The paper identifies and characterizes MTALTCO1, a long mitochondrial alternative protein encoded by an ORF within the cytochrome oxidase 1 gene, challenging existing models of mitochondrial codon usage and gene expression.
Philosophical Transactions of the Royal Society B Biological Sciences · Apr 2, 2026Peer-reviewedMolecular Biology