Xavier Roucou

The paper identifies 25% of 7,264 non-canonical open reading frames (ncORFs) as producing translated gene products, supported by over 3,000 peptides from 3.8 billion mass spectra.

The paper integrates a comprehensive loss-of-function dataset with ncORF information in Medicago truncatula, revealing their potential impact on phenotypes and highlighting ambiguities in mutant studies.

The paper identifies and characterizes MTALTCO1, a long mitochondrial alternative protein encoded by an ORF within the cytochrome oxidase 1 gene, challenging existing models of mitochondrial codon usage and gene expression.

The paper expands and refines a reference catalog of human non-canonical open reading frames (ncORFs) by incorporating more datasets and introducing a translation signature score framework to prioritize high-quality ncORFs.

The paper assesses MS-based identifications of unannotated human microproteins, finding large variation in reported proteins and PSM quality across studies.

The paper identifies chimeric peptides and potential mosaic proteins in Medicago truncatula proteomic data, providing indirect evidence for the mosaic translation hypothesis.

The paper identifies a functional pseudogene, RPS27AP5, that produces ubiquitin and ribosomal protein variants involved in specialized ribosomal functions and transcriptional regulation.

The paper identifies altPIDD1 as the primary protein product of the PIDD1 gene, showing higher expression and cytoskeletal interactions compared to the known PIDD1 protein.

The paper identifies 280 alternative proteins in human protein-protein interaction networks using proteogenomic data and experimental validation, revealing new interactions and functional roles.

This paper outlines a community-driven initiative to create a consolidated catalog of human Ribo-seq ORFs, addressing the lack of standardized annotation for these features.

The paper identifies a new protein, MTALTND4, encoded by an alternative ATG in the human mitochondrial nd4 gene, which affects mitochondrial bioenergetics.

The paper identifies an alternative open reading frame (altORF) within the FUS gene that contributes to toxicity in neurodegenerative models.