Structural basis for no retinal binding in flotillin-associated rhodopsins
Kirill Kovalev, Artem Stetsenko, Florian Trunk, Egor Marin, Jose Manuel Haro-Moreno, Gerrit H. U. Lamm, Alexey A. Alekseev, Francisco Rodriguez-Valera, Thomas R. Schneider, Josef Wachtveitl, Albert Guskov
The paper presents cryo-EM structures of FArhodopsin and proteorhodopsin, showing no retinal binding despite conserved lysine and similar fold to retinal-binding rhodopsins, with mutations identified that prevent retinal binding.
Structure · Jul 15, 2025Peer-reviewedBiophysics