Temporal perturbation of STAT1/2 activity reveals dynamic ligand discrimination of type I interferon signaling
Haowen Yang, Thomas van de Kreeke, Laura C. Van Eyndhoven, Jurjen Tel
The paper investigates how STAT1/2 activity differs in response to IFN and IFNβ through temporal perturbation, revealing distinct signaling dynamics and refractory states.
bioRxiv · Mar 27, 2023 · PreprintSystems Biology