Mitochondria-dependent phase separation of disease-relevant proteins drives pathological features of age-related macular degeneration
Nilsa La Cunza, Li Xuan Tan, Thushara Thamban, Colin J. Germer, Gurugirijha Rathnasamy, Kimberly A. Toops, Aparna Lakkaraju
This study identifies mitochondrial stress-mediated protein phase separation as a key pathogenic mechanism in AMD, linking genetic risk factors to RPE dysfunction.
JCI Insight · Apr 6, 2021Peer-reviewedNeuroscience