Coupling fibroblast mechanotransduction signaling to tissue growth in a multiscale model of skin expansion
Laura Nunez-Alvarez, Joanna K. Ledwon, Parul Rai, Kathryn R. Reisner, Tianhong Han, Luis Solorio, Arun Kumar Gosain, Adrián Buganza Tepole
This paper develops a multiscale model coupling fibroblast mechanotransduction signaling to tissue growth, showing tension-dependent regulation and bidirectional mechanical-biochemical coupling in skin expansion.
bioRxiv · Aug 3, 2026 · PreprintBiophysics