Adrián Buganza Tepole

This paper develops a multiscale model coupling fibroblast mechanotransduction signaling to tissue growth, showing tension-dependent regulation and bidirectional mechanical-biochemical coupling in skin expansion.

This study investigates the mechanical and biological changes in mouse pressure ulcers over time, showing how tissue deformation, inflammation, and collagen remodeling co-evolve during ulcer formation and healing.

This study develops a computational model of inflammation and vascular remodeling in breast cavity healing after lumpectomy, calibrated with experimental data to predict healing outcomes.

This paper develops a framework to estimate volumetric capillary density from histological vascular measurements by generating 3D capillary networks that match experimental data.

This paper introduces a Bayesian framework using active membranes to infer skin biomechanical properties from strain fields without direct force measurements.

CalciumInsights provides a user-friendly tool for analyzing calcium signals across multiple organisms and tissues without requiring programming expertise.

This study shows ROS inhibit myosin phosphorylation to counteract wound contraction, delay closure, and impair regrowth, while chronic ROS depletion alters tissue stiffness and impairs healing.

This paper identifies a pivot-clip mechanism that enhances 5β1 integrin-fibronectin binding dynamics, reinforcing cell adhesion through conformational changes induced by mechanical forces.