Auto-sumoylation of UBC9 coordinates meiotic prophase and protects ovarian reserves
Sunkyung Lee, Tianhong Lu, Dhananjaya S. Kulkarni, Delin Zhang, Britney Ly, Sida Li, Megan Sarringhaus, Yungdae Ryu, Neil Hunter
This study shows that UBC9 auto-sumoylation coordinates meiotic prophase and maintains ovarian reserves by modifying SYCP3 and affecting recombination and synapsis.
bioRxiv · Aug 9, 2026 · PreprintGenetics