Neil Hunter

This study shows that UBC9 auto-sumoylation coordinates meiotic prophase and maintains ovarian reserves by modifying SYCP3 and affecting recombination and synapsis.

This study shows that age-related changes in cohesion strength in oocytes lead to different types of chromosome segregation errors in eggs from young and old females.

This study determines the molecular structure and function of HEI10, revealing its role in ubiquitin chain formation during meiosis.

The paper shows Polycomb complexes regulate active chromatin remodeling during ovarian reserve formation and oocyte growth, establishing quiescence and future promoter states through distinct H3K27ac and H3K4me3 dynamics.

This study identifies mechanisms by which Mre11 is recruited during meiosis to initiate recombination in budding yeast.

This study shows SUMO levels correlate with crossover rates across vertebrate species and within goat breeds, suggesting SUMO modulates meiotic crossover variation.

This study shows SUMO regulates meiotic chromosome length and crossover rate in mice by affecting chromatin loop and axis organization.

This study identifies HEIP1 as a master regulator of crossover formation in mouse meiosis by orchestrating the recruitment of pro-crossover proteins.

This study shows that synaptonemal complex components protect double-Holliday junctions to ensure crossover recombination during meiosis.

This study shows that non-growing oocytes in mice have pre-established epigenetic marks that prime the epigenome for oocyte maturation and early embryogenesis, challenging the traditional view that these marks are acquired after ovarian reserve exit.

The paper investigates the distinct and interdependent roles of three RING proteins in regulating meiotic recombination in mice, revealing their unique spatiotemporal dynamics and functional relationships.

The paper identifies 2747 SUMO modification sites in budding yeast meiosis, revealing SUMO's role in chromosome organization and recombination.

This study shows maternal obesity increases chromosome abnormalities in oocytes, likely due to weakened sister-chromatid cohesion, and this effect is more pronounced in older mice.

This study shows RNF212 mediates oocyte quality control by impeding DNA break repair during meiosis, ensuring defective eggs are eliminated.

This study shows that MutSγ activation during meiosis depends on Cdc7-mediated phosphorylation of Msh4, stabilizing the complex and enabling crossover formation.

The paper shows that SUMO and ubiquitin-proteasome systems regulate meiotic prophase events in mouse by controlling protein turnover through RNF212 and HEI10.