Author

Tianyu Lei

Lanzhou UniversityPrimary ORCID profile (0000-0001-8774-1685 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Tianyu LeiiD2 papers · North China University of Science and Technology

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:Ribo-seq· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Hong ZhangiD· 3 shared Yue ChangiD· 3 shared Chao Yao· 1 shared Feng ZhouiD· 1 shared Jiawen JiangiD· 1 shared Yucheng HuangiD· 1 shared Ziyang ZhuiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 17 mutual co-author links

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3 shared papersGenomics

Hong ZhangORCID

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3 papers

Recent·Most cited

Evolutionary remodeling of non-canonical ORF translation in mammals

Yue Chang, Tianyu Lei, Feng Zhou, Jiawen Jiang, Yucheng Huang, Ziyang Zhu, Hong Zhang

The paper identifies and characterizes non-canonical ORFs in mammals, showing their evolutionary conservation and functional integration into the proteome.

bioRxiv · Sep 16, 2025 · PreprintGenomics

A systematic evaluation revealed that detecting translated non-canonical ORFs from ribosome profiling data remains challenging

Tianyu Lei, Yue Chang, Chao Yao, Hong Zhang

The paper evaluates four methods for detecting translated non-canonical ORFs from Ribo-Seq data and finds they have low precision and accuracy, especially for ORFs with near-cognate start codons.

Journal of genetics and genomics/Journal of Genetics and Genomics · Sep 4, 2023Peer-reviewedGenomics

PSite: inference of read-specific P-site offsets for ribosomal footprints

Yue Chang, Tianyu Lei, Hong Zhang

PSite infers read-specific P-site offsets for ribosomal footprints, improving ORF prediction and robustness to dataset quality and cutting bias.

bioRxiv · Jun 27, 2023 · PreprintBioinformatics