Author

Tijda Argun

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Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 1 Approach:experimental assay· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

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Amy Gilson· 1 shared Eugene Shakhnovich· 1 shared Jin Yan· 1 shared Sanchari Bhattacharyya· 1 shared Shimon Bershtein· 1 shared Sunia Trauger· 1 shared

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2016-2016 · peak 1/yr

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1 shared paperSystems Biology

Amy Gilson

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1 paper

Recent·Most cited

Transient protein-protein interactions perturb E.coli metabolome and cause gene dosage toxicity

Sanchari Bhattacharyya, Shimon Bershtein, Jin Yan, Tijda Argun, Amy Gilson, Sunia Trauger, Eugene Shakhnovich

This study shows that overexpression of DHFR in E. coli causes metabolic imbalance and gene dosage toxicity through interactions with metabolic enzymes, while orthologous DHFRs from other species show reduced effects due to evolutionary divergence.

bioRxiv · Jul 27, 2016Systems Biology