Author

Sanchari Bhattacharyya

Primary ORCID profile (0000-0003-3421-4755 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Sanchari BhattacharyyaiD1 paper · Albert Einstein College of Medicine

Biology Disciplines

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Systems Biology· 2

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Eugene Shakhnovich· 2 shared Shimon Bershtein· 2 shared Adrian Serohijos· 1 shared Amy Gilson· 1 shared Jeong-Mo Choi· 1 shared Jin Yan· 1 shared Jingwen Zhou· 1 shared Michael Manhart· 1 shared

Activity by Year

2015-2016 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersSystems Biology

Eugene Shakhnovich

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2 papers

Recent·Most cited

Transient protein-protein interactions perturb E.coli metabolome and cause gene dosage toxicity

Sanchari Bhattacharyya, Shimon Bershtein, Jin Yan, Tijda Argun, Amy Gilson, Sunia Trauger, Eugene Shakhnovich

This study shows that overexpression of DHFR in E. coli causes metabolic imbalance and gene dosage toxicity through interactions with metabolic enzymes, while orthologous DHFRs from other species show reduced effects due to evolutionary divergence.

bioRxiv · Jul 27, 2016Systems Biology

Protein homeostasis imposes a barrier on functional integration of horizontally transferred genes in bacteria

Shimon Bershtein, Adrian Serohijos, Sanchari Bhattacharyya, Michael Manhart, Jeong-Mo Choi, Wangmen Mu, Jingwen Zhou, Eugene Shakhnovich

This study shows that protein homeostasis limits the functional integration of horizontally transferred genes in bacteria by reducing the abundance of foreign proteins, and that this barrier can be overcome through evolutionary adaptation.

bioRxiv · Sep 1, 2015Systems Biology