Protocol for Non-viral HDR-based CRISPR/Cas9 platform for small custom editing in primary T cells
Katariina Mamia, Anniken Solveig Matheson Sollano, Vanja Lundberg, Svetlana Vakkilainen, Eliisa Kekäläinen, Camilla Schalin-Jäntti, Eira Leinonen, Børre Fevang, Juha Grönholm, Timi Martelius, Shiva Dahal‐Koirala, Emma Maria Haapaniemi
This paper presents a non-viral HDR-based CRISPR/Cas9 protocol for editing primary T cells with up to 80% HDR efficiency, targeting small pathogenic variants in patient and healthy donor cells.
Frontiers in Genome Editing · Sep 30, 2026Peer-reviewedMolecular Biology