Endothelial decorin is increased by ageing and, induces inflammation and diastolic dysfunction in the heart
Guillermo Luxán, Timm Winkelmeier, Colin Bodemer, Büşra Nur Toğru, Mariana Shumliakivska, Marion Muhly-Reinholz, Ariane Fischer, Mariano Ruz Jurado, David John, Wesley Tyler Abplanalp, Stefanie Dimmeler
This study identifies decorin as a factor induced by aging that contributes to cardiac inflammation and diastolic dysfunction through pro-inflammatory effects in the myocardium.
bioRxiv · Feb 14, 2025 · PreprintPhysiology