Wesley Tyler Abplanalp

The paper examines age-related clonal hematopoiesis and mosaic sex chromosome loss in UK Biobank participants, finding distinct proteomic programs and disease associations for each.

The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.

This study shows that loss of KDM6A in hematopoietic cells impairs cardiac recovery after heart failure by causing epigenetic changes in myeloid cells that increase inflammation and worsen cardiac outcomes.

This paper uses single-nucleus RNA sequencing to analyze HFpEF myocardium, identifying transcriptional changes in cardiomyocytes, endothelial cells, fibroblasts, and macrophages that suggest metabolic, inflammatory, and fibrotic mechanisms.

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

This study identifies decorin as a factor induced by aging that contributes to cardiac inflammation and diastolic dysfunction through pro-inflammatory effects in the myocardium.

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.