ACC1-Dependent De Novo Lipogenesis Sustains Hematopoietic Stem Cell Quiescence and Self-Renewal
Morgan Jones, Andrew DeVilbiss, Timothy A Liang, S. Matono, Zhiyu Zhao, Adam Ross, Daniel Cassidy, Sean J. Morrison, Qing Li
This study shows that ACC1-dependent de novo fatty acid synthesis is essential for maintaining HSC quiescence and self-renewal, with its loss leading to impaired function and increased fatty acid oxidation.
bioRxiv · Jun 8, 2026 · PreprintCell Biology