Sean J. Morrison

This study shows that ascorbate deficiency in hematopoietic cells promotes leukemogenesis and identifies ascorbate as a tumor suppressor metabolite in blood cancers.

This study shows that glutathione is essential for proteostasis in hematopoietic stem cells but not for ferroptosis prevention.

The paper identifies LepR+ cells as a niche for thrombopoiesis by producing CXCL14, which regulates lipid metabolism and terminal differentiation in megakaryocytes.

This study shows that SCF produced locally in bone marrow stromal and endothelial cells supports hematopoietic stem and progenitor cell maintenance, while systemic SCF does not.

This study shows that ACC1-dependent de novo fatty acid synthesis is essential for maintaining HSC quiescence and self-renewal, with its loss leading to impaired function and increased fatty acid oxidation.

Sustained interferon exposure in inflamed tumor regions enhances metastatic potential of melanoma cells via increased CD47 expression, protecting them from macrophage phagocytosis.

The paper introduces u-Segment3D, a tool that converts 2D cell segmentations into 3D consensus segmentations without training data, demonstrating effectiveness across diverse datasets.

The paper introduces MCT-ASLM, a microscopy platform that enables subcellular resolution imaging of whole tissues, demonstrating its application in studying neuronal circuits, kidney innervation, and tumor microenvironments.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.

This study identifies integrin alpha11 as the receptor for Osteolectin, showing its role in osteogenic differentiation and bone mass maintenance through Wnt pathway activation.