Author

Timothy DeSmet

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 2

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Approach:benchmark study· 1 Organism:human· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Sheila Dodge· 2 shared Steven Ferriera· 2 shared Abebaw FekaduiD· 1 shared Alicia R. MartiniD· 1 shared Anne StevensoniD· 1 shared Benjamin M. NealeiD· 1 shared Bizu GelayeiD· 1 shared Brian R. Granger· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenomics

Sheila Dodge

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2 papers

Recent·Most cited

Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations

Alicia R. Martin, Elizabeth G. Atkinson, Sinéad B. Chapman, Anne Stevenson, Rocky E. Stroud, Tamrat Abebe, Dickens Howard Akena, Melkam Alemayehu Kebede, Fred K. Ashaba, Lukoye Atwoli, Tera Bowers, Lori Beth Chibnik, Mark J. Daly, Timothy DeSmet, Sheila Dodge, , Zukiswa Zingela

This study shows low-coverage sequencing is more accurate and cost-effective than GWAS arrays for detecting genetic variation in diverse African populations.

The American Journal of Human Genetics · Mar 25, 2021Peer-reviewedGenomics

Characterization and remediation of sample index swaps by non-redundant dual indexing on massively parallel sequencing platforms

Maura Costello, Mark Fleharty, Justin Abreu, Yossi Farjoun, Steven Ferriera, Laurie Holmes, Brian R. Granger, Lisa Green, Tom Howd, Tamara Mason, Gina Vicente, Michael Dasilva, Wendy Brodeur, Timothy DeSmet, Sheila Dodge, , Stacey Gabriel

The paper characterizes index swapping on Illumina sequencers and proposes dual indexing to mitigate its effects, showing varying swap rates across methods and sequencers.

BMC Genomics · May 8, 2018Peer-reviewedGenomics