Author

Maura Costello

Broad InstituteORCID 0000-0002-0281-3035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:long-read sequencing· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Kiran V. GarimellaiD· 2 shared Stacey GabrieliD· 2 shared Tera Bowers· 2 shared Allyson Day· 1 shared Alper GokdeniD· 1 shared Anthony PhilippakisiD· 1 shared Aziz M. Al’KhafajiiD· 1 shared Beryl B. CummingsiD· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersGenetics

Kiran V. GarimellaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

High-throughput RNA isoform sequencing using programmable cDNA concatenation

Aziz M. Al’Khafaji, Jonathan T. Smith, Kiran V. Garimella, Mehrtash Babadi, Victoria Popic, Moshe Sade-Feldman, Michael Gatzen, Siranush Sarkizova, Marc A. Schwartz, Emily M. Blaum, Allyson Day, Maura Costello, Tera Bowers, Stacey Gabriel, Eric Banks, , Nir Hacohen

This paper introduces MAS-ISO-seq, a method to boost throughput of long-read RNA sequencing for isoform discovery, showing improved detection of differentially spliced genes and cell clustering in T cells.

Nature Biotechnology · Jun 8, 2023Peer-reviewedGenetics

Transcriptome variation in human tissues revealed by long-read sequencing

Dafni A. Glinos, Garrett Garborcauskas, Paul Hoffman, Nava Ehsan, Lihua Jiang, Alper Gokden, Xiaoguang Dai, François Aguet, Kathleen L. Brown, Kiran V. Garimella, Tera Bowers, Maura Costello, Kristin Ardlie, Ruiqi Jian, Nathan R. Tucker, , Beryl B. Cummings

The paper uses long-read RNA-seq data to identify new transcripts and develop a tool to analyze genetic effects on transcript structure, revealing insights into splicing regulation and variant interpretation.

Nature · Aug 3, 2022Peer-reviewedGenomics

Characterization and remediation of sample index swaps by non-redundant dual indexing on massively parallel sequencing platforms

Maura Costello, Mark Fleharty, Justin Abreu, Yossi Farjoun, Steven Ferriera, Laurie Holmes, Brian R. Granger, Lisa Green, Tom Howd, Tamara Mason, Gina Vicente, Michael Dasilva, Wendy Brodeur, Timothy DeSmet, Sheila Dodge, , Stacey Gabriel

The paper characterizes index swapping on Illumina sequencers and proposes dual indexing to mitigate its effects, showing varying swap rates across methods and sequencers.

BMC Genomics · May 8, 2018Peer-reviewedGenomics