SARS-CoV-2 Infection of Salivary Glands Compromises Oral Antifungal InnateImmunity and Predisposes to Oral Candidiasis
Areej A. Alfaifi, Tristan W. Wang, Paola Pérez, Ahmed S. Sultan, Timothy F. Meiller, Peter Rock, David Erwin Kleiner, Daniel S. Chertow, Stephen M. Hewitt, Billel Gasmi, Sydney R. Stein, Sabrina C. Ramelli, Daniel Martı́n, Blake M. Warner, Mary Ann Jabra‐Rizk
This study shows SARS-CoV-2 infection reduces histatin-5 in salivary glands, impairing antifungal immunity and increasing Candida albicans prevalence in COVID-19 patients.
PLoS Pathogens · Dec 12, 2024Peer-reviewedMicrobiology