Daniel Martı́n

ZBTB7B is a Master Regulator of Salivary Acinar Cell Function

The paper identifies ZBTB7B as a master regulator of salivary acinar cell function through transcriptional and regulatory analyses in human and mouse salivary glands.

Exhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset

This study identifies exhausted-like effector CD8 T cells as key drivers of oral mucosal cGVHD by analyzing single-cell RNA sequencing data from biopsies collected at disease onset.

Human ectodermal organoids reveal the cellular origin of DiGeorge Syndrome

The paper uses human ectodermal organoids to study DiGeorge Syndrome, showing defects in neural crest development and identifying key genes involved.

SARS-CoV-2 Infection of Salivary Glands Compromises Oral Antifungal InnateImmunity and Predisposes to Oral Candidiasis

This study shows SARS-CoV-2 infection reduces histatin-5 in salivary glands, impairing antifungal immunity and increasing Candida albicans prevalence in COVID-19 patients.

Transcriptomic signature and pro-osteoclastic secreted factors of abnormal bone marrow stromal cells in fibrous dysplasia

This study identifies a transcriptomic signature and secreted factors from Gs-activated BMSCs in fibrous dysplasia, linking them to pro-inflammatory and pro-osteoclastic behavior and potential therapeutic targets.

Single-cell atlas of human oral mucosa reveals a stromal-neutrophil axis regulating tissue immunity in health and inflammatory disease

This paper constructs a single-cell transcriptome atlas of human oral mucosa in health and periodontitis, identifying a stromal-neutrophil axis regulating tissue immunity.

ZCCHC8 is required for the degradation of pervasive transcripts originating from multiple genomic regulatory features

This study identifies ZCCHC8's role in degrading pervasive transcripts from various genomic regions, suggesting it regulates non-coding RNA beyond previously known substrates.

Characterizing Adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq: Validation in the adult mouse and translational implications for the adult human cochlea

The paper characterizes adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq in mice and validates findings in humans, identifying potential mechanisms for cochlear regeneration.

Single cell and single nucleus RNA-Seq reveal cellular heterogeneity and homeostatic regulatory networks in adult mouse stria vascularis

The paper uses single cell and single nucleus RNA-sequencing to identify cell populations and gene regulatory networks in adult mouse stria vascularis, linking known deafness genes to specific cell types.