David Erwin Kleiner

The paper develops a perfusion circuit system to preserve tumor microenvironments in 3D patient-derived tumor models for up to 48 hours, enabling complex drug interrogations.

This study identifies exhausted-like effector CD8 T cells as key drivers of oral mucosal cGVHD by analyzing single-cell RNA sequencing data from biopsies collected at disease onset.

This study shows SARS-CoV-2 infection reduces histatin-5 in salivary glands, impairing antifungal immunity and increasing Candida albicans prevalence in COVID-19 patients.

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

The paper introduces TACIT, an unsupervised algorithm for cell type annotation in spatial biology, showing improved accuracy and scalability across multiple datasets and applications.

This study identifies de novo LYN variants causing constitutive Lyn kinase activation, leading to neutrophilic vasculitis and liver fibrosis, and shows therapeutic response to Src kinase inhibitors.

This study compares hepatic gene expression in adolescents and adults with NAFLD, finding some similarities but major differences in transcriptomic profiles associated with disease severity.