Context-dependent utility and robustness of pretrained single-cell foundation model representations across analytical tasks
Tianyuan Liu, Tingze Feng, Xianrun Pan, Yangyang Chen, Liping Ren, Xiucai Ye, H Y Lin, Yu Zhang
This study evaluates the zero-shot performance of single-cell foundation models across tasks and datasets, showing task-dependent utility and structural robustness vary with dataset characteristics.
bioRxiv · Jul 13, 2026 · PreprintBioinformatics