Yu Zhang

PA-SfM enables tracker-free freehand 3D photoacoustic imaging with improved spatial coverage and reconstruction quality compared to traditional methods.

This paper introduces GO-CRE, a method for designing cell-type-specific cis-regulatory elements by reconstructing sequence-grammar trajectories and using reinforcement learning with predictor guidance.

This study evaluates the zero-shot performance of single-cell foundation models across tasks and datasets, showing task-dependent utility and structural robustness vary with dataset characteristics.

This study identifies Drosophila Ciz1 as a factor that prevents oxidative stress and maintains epithelial homeostasis during wing development.

This paper maps breast cancer evolution in situ using spatial transcriptomics and other data to show that tumor progression is driven by spatially coherent fronts rather than predefined clonal branches.

This paper develops a hydrogel-based therapy using functionalized Bifidobacterium longum to treat colitis-associated anxiety and depression by targeting both gut and brain inflammation.

The paper investigates gut microbiota dysbiosis in hypertension and its interactions with the host immune system using multi-omics data and single-cell analysis.

This study identifies FAN and FIP1 as ribosome biogenesis factors in Arabidopsis, showing their role in BR signaling and heat tolerance through pre-rRNA processing and translation efficiency of BRI1.

The paper introduces CombiDOCK and MINT-Dock to efficiently screen large molecule libraries for ligand discovery, achieving high hit rates and computational efficiency.

This study shows closed-loop neurofeedback can reshape preparatory brain states, reducing pain perception by altering neural dynamics and microstate transitions.

This study identifies glucocorticoids as mediators of hypoxic memory in erythrocytes that enhance oxygen delivery and reduce AMS severity through metabolic reprogramming.

This study reveals that PD-1 remodels SHP2 dynamics to inhibit T cell activation through a non-catalytic mechanism, independent of its phosphatase activity.

This study identifies Glce as a non-enzymatic regulator of hippocampal dendritic integrity and stress resilience through direct activation of PI3K, revealing a novel mechanism in depression pathophysiology.

This study identifies 5 transferred metabolites and 668 mobile genes between Thesium chinense and its host Prunella vulgaris, revealing information exchange critical for haustoria formation and parasitism.