Author

Tianzhi Wu

University of California, San Francisco

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:metagenomics· 1

Frequent Co-Authors

Arnold R. KriegsteiniD· 2 shared Jingjing LiiD· 2 shared Tanzila MukhtariD· 2 shared Cheng Wang· 1 shared Clara SiebertiD· 1 shared Erqiang HuiD· 1 shared Guangchuang YuiD· 1 shared Guolong ZuoiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersNeuroscience

Arnold R. KriegsteinORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Single Cell Proteomics in the Developing Human Brain

Tianzhi Wu, Lihua Jiang, Tanzila Mukhtar, Li Wang, Ruiqi Jian, Cheng Wang, Tiffany Trinh, Arnold R. Kriegstein, Michael P. Snyder, Jingjing Li

This study develops a single-cell proteomics workflow to analyze the developing human brain, revealing transcriptome-proteome discordance and identifying molecular vulnerabilities in neurodevelopmental disorders.

Nature Biotechnology · Jan 27, 2026Peer-reviewedNeuroscience

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

Tanzila Mukhtar, Clara Siebert, Yuejun Jessie Wang, Mark-Phillip Pebworth, Matthew L. White, Tianzhi Wu, Tao Huang, Guolong Zuo, Jayden M. Ross, Jennifer Baltazar, Varun Upadhyay, Merut Shankar, Li Zhou, Isabel Lombardi-Coronel, Ishaan Mandala, , Arnold R. Kriegstein

This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.

Nature Communications · Jul 1, 2025Peer-reviewedNeuroscience

clusterProfiler: An universal enrichment tool for functional and comparative study

Tianzhi Wu, Erqiang Hu, Shuangbin Xu, Meijun Chen, Pingfan Guo, Zehan Dai, Tingze Feng, Lang Zhou, Wenli Tang, Li Zhan, Xiaocong Fu, Shanshan Liu, Xiaochen Bo, Guangchuang Yu

clusterProfiler performs over-representation (Fisher's exact test) and gene set enrichment analyses on Gene Ontology, KEGG, and user-supplied annotations, supporting non-model organisms, multi-condition comparisons, and ggplot2-based visualization.

The Innovation · Jul 1, 2021Peer-reviewedBioinformatics✦ In-depth digest