Advancing Liver Gene Therapy: Enhanced Transduction with GalNAc-Bioconjugated rAAV Capsids
Pierre-Alban Lalys, Audrey Bourdon, Mohammed Bouzelha, Dimitri Álvarez‐Dorta, Karine Pavageau, Tiphaine Girard, Roxane Peumery, Zakaria Bouchouireb, Maia Marchand, Anthony Mellet, Nicolas Jaulin, Mireille Ledevin, Olivia Terceve, Sébastien Depienne, Mickaël Guilbaud, , David Deniaud
This study enhances liver gene therapy by conjugating GalNAc to rAAV capsids, improving transduction efficiency in mice while reducing required dosages.
Biomedicine & Pharmacotherapy · Jun 27, 2025Peer-reviewedBioengineering