NeurosciencebioRxivPreprint
Genetic mechanisms for impaired synaptic plasticity in schizophrenia revealed by computational modelling
Tuomo Mäki‐Marttunen, Kim T. Blackwell, Ibrahim A. Akkouh…·Ole A. Andreassen
The paper uses computational modeling and post-mortem gene expression data to show that schizophrenia-associated genes impair PKA-mediated LTP in GluR1-containing synapses, linking genetic factors to synaptic plasticity deficits.
DOI 10.1101/2023.06.14.544920