Ibrahim A. Akkouh

The paper identifies a schizophrenia-specific alternative splicing program in cortical brain organoids that responds to clozapine treatment.

This study shows muscimol, a non-classic psychedelic, reduces inflammation and promotes neuroplasticity in schizophrenia-derived human cortical spheroids and astrocytes by modulating GABAA receptors.

This study develops a spiking network model of auditory novelty detection and shows how SCZ-related cellular changes impair mismatch negativity.

Bivariate GSA-MiXeR is a tool that models genetic correlations between two traits to identify genomic regions associated with psychiatric and neurodegenerative disorders using single-cell RNA sequencing data.

The paper uses computational modeling and post-mortem gene expression data to show that schizophrenia-associated genes impair PKA-mediated LTP in GluR1-containing synapses, linking genetic factors to synaptic plasticity deficits.

This study shows that SETD1A loss-of-function mutations increase dendritic complexity and neuronal bursting in human neurons via a hyperactive cAMP/PKA pathway, which can be rescued by pharmacological intervention.

This study uses a human iPSC-derived astrocyte model to identify SCZ-specific transcriptomic and functional changes in astrocytes, revealing altered gene expression and biological processes.

The paper introduces a synthetic voltage sensor and optogenetic actuator for all-optical electrophysiology in hiPSC-derived neurons, demonstrating its effectiveness in measuring activity across distinct genetic backgrounds.