Allosteric Inhibition of NDM-1 by Thanatin Preserves the Di-Zinc Center While Restricting Dynamics
Gwladys Rivière, Prince Kumar, Tom Cummins, Ansel Hsiao, Leonard J. Mueller
This paper reveals that Thanatin inhibits NDM-1 by preserving its zinc center while restricting dynamics, contrasting with zinc-displacement models and showing reduced bacterial viability.
bioRxiv · Feb 27, 2026 · PreprintBiophysics