Proteome-wide impact of LRRK1 and 2 inhibitors on protein interactions and phosphorylation
Jasmin Jansen, Marcel Wendel, Nicolai D. Raig, Tom Kraus, Katherine J. Surridge, Swetha Mahesula, Nicole Richter-Muller, Sebastian Mathea, Samara L. Reck‐Peterson, Stefan Knapp, Florian Stengel
This study uses proximity labeling and phosphoproteomics to analyze LRRK1 and LRRK2 interactomes and phosphorylation sites, identifying novel substrates and the impact of inhibitors.
bioRxiv · Sep 3, 2025 · PreprintMolecular Biology