The vacuolar tauopathy-associated mutation D395G confers redox sensitivity to p97/VCP
Smruti Ranjan Rout, Martin Kulke, Maxim A. Droemer, Marcel Wendel, Tat Cheung Cheng, Tristan Alexander Mauck, Sean Asgari, Antonia A. Nemec, Mikhail Shein, Yusuke Sato, Shuya Fukai, Gregor Witte, Robert J. Tomko, Florian Stengel, Martin Zacharias, , Eri Sakata
This study investigates how the p97/VCP mutation D395G increases redox sensitivity, leading to oxidative inactivation and contributing to neurodegeneration.
bioRxiv · May 4, 2026 · PreprintMolecular Biology