The structural basis of translational control by eIF2 phosphorylation
Tomas Adomavicius, Margherita Guaita, Yu Zhou, Martin D. Jennings, Zakia Latif, Alan M. Roseman, Graham D. Pavitt
This study determines the structures of phosphorylated and unphosphorylated eIF2 bound to eIF2B, revealing how eIF2 phosphorylation modulates translational control through altered binding affinity.
Nature Communications · May 13, 2019Peer-reviewedMolecular Biology